Langerhans cell histiocytosis is categorized as single‐system LCH (SS‐LCH) with multifocal or unifocal involvement, or as multisystem LCH (MS‐LCH) with multiple organ involvement with or without risk organ involvement. Organs at risk include the hematopoietic system . Thus, cladribine has major activity in adult LCH and warrants further investigation in both pediatric and adult LCH as a single agent and in combination with other drugs. View Show abstract.
Saven A, Burian C () Cladribine activity in adult Langerhans cell histiocytosis. Blood Adam Z, Szturz P, Duras J, Pour L, Kreji M, et al. () Treatment of Langerhans cell histiocytosis by cladribine reached long-term complete remission in 9 out of 10 adult patients. Klin Onkol Author: Marlies E.H.M. van Hoef. Cladribine was administered to 13 LCH patients at mg/kg per day by 2-hour intravenous infusion for 5 consecutive days, every 4 weeks for a maximum of six courses. Median age was 42 years (range, 19 to 72) and median pretreatment disease duration was 99 months (range, 6 to ).Cited by:
Jun 15, · Only one patient had a documented infection, dermatomal herpes zoster. At a median follow-up of 42 months (range, 5 to 76), 12 patients remain alive and one patient has died. Thus, cladribine has major activity in adult LCH and warrants further investigation in both pediatric and adult LCH as a single agent and in combination with other drugs. The dosing of cladribine for all patients was based on one of the two intravenous regimens ( mg/kg for days every 28 days or 5 mg/m 2 for days every 28 days). The median follow-up for the entire cohort was years (95% CI) and the treatment outcomes are shown in Table anuses.xyz by: 1.